Tranny wrote:"He doesn't loose sleep over me."
Your sentence is not English. What you really heard was:
"He doesn't lose
sleep over me."
is an adjective with several meanings: not firmly or tightly fixed in place; not fitting tightly; relaxed, not strict
is a verb meaning be deprived of or cease to have
Lose is pronounced with a /z/ sound (/looz/).
Loose is pronounced with an /s/ sound (/loos/).
You probably didn't hear the /z/ sound because of the /s/ sound in sleep.
The meaning is something like:
He doesn't care about me. He doesn't worry about me. I don't stop him sleeping.