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a. You who are his friends should talk to him about this.
b. You, who are his friends should, talk to him about this.

c. We who are his friends should talk to him about this.
d. We, who are his friends should, talk to him about this.

What is the difference between (a) and (b), and between (c) and (d)?

In (b) and (c) it is clear that 'all of you' and 'all of us', respectively, are his friends.

Does (a) mean: "Those of you who are his friends should talk to him about this."?

Does (c) mean: "Those of us who are his friends should talk to him about this."?

Many thanks

Two of your sentences were incorrectly punctuated.
-->b. You, who are his friends, should talk to him about this.
-->d. We, who are his friends, should talk to him about this.

There is no significant difference between the pairs. ('We' automatically means 'all of us' and 'you' = 'all of you').